| ncRNA name | p22phox siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Homo sapiens |
| Tissues/Cell_line | human primary RPE cells (hRPE) |
| Methods | siRNA transfection, immunoprecipitation, immunoblot, qPCR |
| Expression pattern | associated |
| Functional description | TNF-α induced ROS generation and increased activation of NOX4, an isoform of NADPH oxidase; both were prevented by pretreatment with the apocynin or VAS2870 or knockdown of p22phox, a subunit of NADPH oxidase. |
| PubMed ID | 26900328 |
| Year | 2016 |
| Title | TNF-α mediates choroidal neovascularization by upregulating VEGF expression in RPE through ROS-dependent β-catenin activation. |
| Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.